1) Yes you can disable Weekends. Choose the option, "Disable Weekend Dates"
2) For disabling a specific day of the week (that is, to choose a check box to disable every Monday, or whatever), I cant see an option for that. You can select specific dates however, (choose them from the calendar pop-up), so effectively using that option you can then go through and choose every Monday occurrence (a bit tedious but it is a work-around). There is no current option to actually choose "every (such and such) week day".